Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
نویسندگان
چکیده
منابع مشابه
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
Piperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350mg/kg, i.p.) was administered 30min after piperine (2.5, 5, 10 and 20mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These parameters were also increased in the piloc...
متن کاملEffects of Propofol on Epileptiform Activity and Hippocampal Morphology in Febrile Convulsions and Pilocarpine Induced Seizures
Epidemiological and recent prospective analyses of long Febrile Seizures (FS) support the idea that such seizures can provoke Temporal Lobe Epilepsy (TLE) in some children. Because of the high prevalence of these seizures, if epilepsy was to arise as their direct consequence, this would constitute a significant clinical problem. Animal studies have revealed that exposure of hippocampal neurons ...
متن کاملEffects of the Aqueous Seed Extract of Withania somnifera ( Ashwagandha ) against Pilocarpine - induced Convulsions in Rats
The present study is designed to investigate effect of Ashwagandha aqueous seed extract against pilocarpine-induced convulsions in rats. Convulsions was induced by pilocarpine injection (300mg/kg, i.p.). After 15 days, the animals were received carbamazepine (100 mg/kg) and Ashwagandha (25 & 50 mg/kg, orally), for 14 days. Death, latencies to the first convulsion and cholinergic signs were obse...
متن کاملCentral mechanisms involved in pilocarpine-induced pressor response
Pilocarpine (cholinergic muscarinic agonist) injected peripherally may act centrally to produce pressor responses; in the present study, using c-fos immunoreactive expression, we investigated the forebrain and brainstem areas activated by pressor doses of intravenous (i.v.) pilocarpine. In addition, the importance of vasopressin secretion and/or sympathetic activation and the effects of lesions...
متن کاملPiperine protects epilepsy associated depression: a study on role of monoamines.
BACKGROUND AND OBJECTIVES In patients with epilepsy, a common comorbidity diagnosed is depression. Temporal lobe epilepsy or post status epilepticus (SE) animal model establish and validate the co morbidity and common pathogenesis of depression and epilepsy. Elevation in serotonin concentration gives an inhibitory response to epileptic discharge and stabilizes the depressed mood disorder. Piper...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2013
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2013.01.002